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KMID : 0985520220270030121
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Korean Journal of Pancreas and Biliary Tract
2022 Volume.27 No. 3 p.121 ~ p.127
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Multi-Center Study on Gender Difference in Resectability and Pathologic Prognosis of Gallbladder Cancer
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Park Yang-Tae
Kang Jin-Hyong
Kim Jae-Seon
Jung Min-Kyu
Kim Seong-Hun
Cho Jae-Hee
Woo Sang-Myung
Lee Kyong-Joo
Kim Eui-Joo
Kim Hyo-Jung
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Abstract
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Background/Aim: In gallbladder cancer (GBC), gender differences in incidence and mortality rates have been reported with geographic variation. However, there is little known about sex-related difference in GBC prognosis. This study compares prognostic factors according to gender for GBC.
Methods: We searched clinicopathological factors in all stages of 952 GBC patients from seven medical centers in Korea. A total of 927 patients were enrolled and surgery with curative resection was performed in 499 patients.
Results: Carbohydrate antigen (≥37 U/mL) was a significant prognostic factor in both females and males (odd ratio [OR], 4.30; 95% confidence interval [CI], 3.13-5.89; p<0.001). Age was a significant factor only in female patients, elderly patients were associated with low resectability and the likelihood of T-stage >2; an independent predictor of poor prognosis via multivariate analysis (OR, 1.03; 95% CI, 1.01-1.05; p=0.005, OR, 1.05; 95% CI, 1.02-1.08; p=0.002). Body mass index (BMI) also showed gender difference, and lower BMI (≤25 kg/m2) was the significant good indicator of multivariate analysis for lymph node metastasis in female patients (OR, 0.42; 95% CI, 0.23-0.77; p=0.005) but, the significant poor indicator of univariate analysis for advanced T-stage in male (OR, 2.79; 95% CI, 1.40-5.54; p=0.003).
Conclusions: These results suggest that there is a possibility of gender difference in GBC prognosis. Age and high BMI were poor prognostic factors for curative resection for female GBC patients.
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KEYWORD
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Gender, Age factors, Body mass index, CA-19-9 antigen, Bilirubin
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